What is R-Lipoic Acid?
R-lipoic acid is the naturally occurring, biologically active form of alpha lipoic acid (ALA). ALA is a sulphur-containing fatty acids that functions as a powerful antioxidant and metabolic cofactor. It is synthesised in small amounts within the human body and is also found in trace quantities in certain foods such as spinach, broccoli and tomatoes.
The body preferentially recognises and utilises R-lipoic acid compared to standard racemic alpha lipoic acid, making it more bioavailable and effective at lower doses.
Health Benefits:
Antioxidant Action
R-lipoic acid is well recognised for its powerful antioxidant capabilities that can help to protect cell membranes, mitochondria, and intracellular structures from oxidative stress. This is key to preserving good health as oxidative stress is strongly linked to the development of various chronic diseases, including cardiovascular and neurodegenerative diseases.
Supports Glucose Metabolism
The benefits of R-lipoic acid for healthy glucose metabolism are well researched and indicate that supplementing R-lipoic acid may help to balance blood glucose levels and improve insulin sensitivity. One study found that treatment with R alpha lipoic acid improved insulin sensitivity and levels of glucose, triglycerides, and LDL‐cholesterol in the blood of rats with type 2 diabetes and metabolic syndrome. Moreover, another study showed that supplementing ALA led to decreased fasting glucose levels, triglycerides and homeostasis model assessment of insulin resistance in patients with metabolic diseases.
Contributes to Nerve Health
Research indicates that R-lipoic acid may support healthy nerve function. For instance, one study found that ALA supported the management of neuropathic pain, which is chronic pain associated with damaged or diseased nerves. This alleviation of neuropathic pain may be the result of r-lipoic acid's antioxidant abilities, and studies show that ALA may effectively contrapose pathways of oxidative stress within nociceptive fibres, which are involved in the transmission of pain signals through the nervous system.
Typical Use:
R-lipoic acid is commonly consumed through dietary supplements, and such products are often formulated to provide metabolic support and aid blood sugar balance, boost antioxidant action, or contribute to nerve health.
Sources:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5464337/
