Lactobacillus casei

What is Lactobacillus casei?

Lactobacillus casei (L. casei) is a beneficial species of lactic acid producing bacteria naturally found in the human gastrointestinal tract. It can survive acidic conditions in the stomach and exposure to bile salts, which allows it to reach the intestines where it can exert its functional effects. This bacteria belongs to a broader group of beneficial microbes commonly referred to as probiotics, that support digestive health and help to restore gut flora.

Health Benefits:

Contributes to Digestive Health

L. casei can support digestive health by contributing to the healthy maintenance of a balanced gut microbiome, with studies suggesting that treatment with L. casei can lead to beneficial changes in overall intestinal microbiota. L. casei produces lactic acid through the fermentation of sugars, which increases the acidity of the gut environment, inhibiting the growth of harmful pathogenic bacteria.

Through supporting digestive health, L. casei may help to address digestive discomfort and relieve symptoms such as bloating, abdominal pain, constipation and diarrhoea. One study found that treatment with the Shirota strain of L. casei effectively relieved symptoms of constipation and found evidence that this was the result of increased levels of pipecolinic acid within the gut.

May Support Immune Function

The link between gut health and immune system function is well established, and so it is no surprise that L. casei may support immune function. Research suggests that L. casei can activate the gut mucosal immune system, primarily through immune cells involved in the innate immune response, such as macrophages and dendritic cells. Moreover, a 3 week pilot study found that treatment with L. casei LTL1879 led to improved immune indicators and inflammatory markers.

Could Help Maintain Gut Barrier Function

Studies indicate that L. casei may be beneficial for gut barrier integrity and may be a valuable way to help treat and prevent the development of a 'leaky gut'. One study found that administration of L. casei helped to prevent cytokine-induced epithelial barrier dysfunctions and increased permeability in intestinal epithelial cells. Furthering this, L. casei may enhance goblet cell activity, meaning goblet cells can better maintain the host barrier by regulating the secretion of mucins which form the protective mucus layer of the gut barrier. This protective mucus layer is responsible for acting as a selective barrier against pathogenic bacteria while supporting beneficial microbiota.

Typical Use:

L. casei is commonly used in probiotic capsules and powders due to its potential digestive and immune system benefits, as well as its resilience against the stomach acid. This probiotic is also often used within functional beverages and fermented dairy products such as yogurts.