Apigenin

What is Apigenin?

Apigenin is a naturally occurring plant flavonoid found in many fruits (e.g. grapefruit), vegetables and herbs including parsley and chamomile. While apigenin does not contribute to the diet in terms of macronutrients, the potent antioxidant activity and rich phytonutrient content of apigenin allows it to provide numerous impressive health benefits.

Health Benefits:

Promotes Sleep and Relaxation

Apigenin has been shown to promote relaxation and naturally support a seamless transition into healthy, restful sleep. Studies have found that oral administration of apigenin can lead to a short-term mild sedative effect as well as reduced locomotor activity in rodents, evidencing that apigenin may have sleep inducing properties. Moreover, chamomile, a rich source of apigenin, has long been recognised for its ability to support good sleep and reduce feelings of anxiety and stress.

Boosts Mood

Research indicates that apigenin may be valuable for enhancing mood and reducing negative emotions, for example the potential for apigenin to alleviate depression has been widely studied and shows promising results. One study found that treatment with apigenin reduced stress induced depression in mice through inhibiting monoamine oxidase A enzyme action. Supporting good mood is not only key to improving quality of life but plays a vital role in supporting physical health as growing evidence shows mood can effect your long term health outcomes and effect things such as risk of diabetes and heart disease.

Anti-inflammatory and Antioxidant Action

As a flavonoid, apigenin is a potent antioxidant and has significant anti-inflammatory capabilities. Evidence suggests that mechanisms of the antioxidant effects of apigenin may include the inhibition of oxidant enzymes, modulation of redox signalling pathways and free radical scavenging. Furthering this, the anti-inflammatory potential of apigenin has been shown through reductions in inflammatory markers/enzymes, for instance one study found that apigenin can reduce the expression and secretion of pro-inflammatory cytokines.

History:

Many of the plants that contain apigenin have long histories of use in traditional herbal medicines. For example, chamomile was often used in Europe and the Middle East for its calming effects, ability to provide digestive comfort, and to gently support sleep. Similarly, parsley was used to treat digestive issues and was highly valued for its diuretic properties.

Typical Use:

Apigenin is typically used as an ingredient in supplements formulated to support sleep, enhance stress management and provide antioxidant defence. Such products are also commonly taken as part of broader longevity or brain health protocols.