TMG

What is TMG?

Trimethylglycine, commonly referred to as TMG or betaine, is a naturally occurring compound derived from the amino acid glycine. It plays an important role in methylation processes within the body, which are key for DNA repair, detoxification, and cardiovascular health. TMG is found in foods such as beetroot, spinach, whole grains and quinoa, and is also produced in the human body. Despite this, levels of TMG can still be deficient for providing maximum support for health, and in such cases it can be highly beneficial to supplement this compound.

Health Benefits:

Cardiovascular Health Support

The TMG found in sugar beets has been shown to decrease blood levels of an amino acid called homocysteine. This amino acid can increase the risk of heart disease if the levels in the blood are too high. Research suggests that taking 4 grams of TMG per day for six weeks could lower homocysteine levels in the blood of healthy adults.

May Enhance Athletic Performance

TMG shows potential benefits for athletic performance, with it suggested to enhance lower body strength, reduce fatigue, boost protein production and increase the production of creatine. This is mostly speculation from athletes however, and more research is needed. One study found that supplementation with TMG led to improvements in the performance of youth professional football players such as their sprint ability and muscular strength.

Could Support Metabolic Health

Various studies suggest that TMG could improve insulin resistance, with one study finding an association between increased intake of choline and betaine with decreased insulin resistance. Two other studies in animals found that TMG improved fat metabolism in mice on a high fat diet and could even reverse insulin resistance in the liver.

Typical Use:

TMG is typically used in powdered or capsule form supplements and is often included in formulations aimed at heart health or sports performance. TMG is frequently combined with nutrients such as folate, vitamin B6, vitamin B12 and choline to support complementary biochemical pathways.