Fisetin

What is Fisetin?

Fisetin is a naturally occurring plant flavonoid found in various fruits and vegetables and can also be derived from the smoke tree (cotinus coggygria). Fisetin is well recognised for its potent antioxidant action and anti-inflammatory properties.

Health Benefits:

Longevity Support

As we age, cells in our bodies can become damaged and then usually die off in a process called autophagy. However some cells do not die when damaged, and instead become senescent cells that damage healthy cells by secreting inflammatory substances and growth factors that accelerate aging. Research evidences that fisetin can help eliminate senescent cells from the body. For instance, one study found that the administration of fisetin to old age mice reduced senescence markers in multiple tissues, reduced age-related pathology, and extended both their median and maximum lifespan. Through aiding in the clearance of senescent cells, fisetin may help alleviate chronic diseases associated with senescent cell build up such as cardiovascular diseases, neurodegenerative diseases and pulmonary fibrosis.

Anti-inflammatory Action

Research has found evidence that fisetin may have powerful anti-inflammatory action that can support overall wellbeing, and reduce symptoms of certain chronic diseases like arthritis and heart disease. One study evidenced that fisetin can inhibit the expression and secretion of inflammatory cytokines, suggesting that fisetin's gene regulating properties may contribute to the flavonoids anti-inflammatory action.

History:

While fisetin was not historically used as a stand alone ingredient, foods naturally rich in fisetin, such as strawberries, onions, and persimmons, have a long history of being consumed as food and were highly valued in various cultures for their health promoting properties.

Typical use:

While fisetin can be consumed through a balanced healthy diet, the levels of fisetin found in foods are very low, meaning that many people choose to take a capsule or powder form fisetin supplement to reach optimal doses and obtain their desired health benefits.