{"title":"Newsletter","description":"","products":[{"product_id":"butishield","title":"Calcium Butyrate Postbiotic – ButiShield™ 35% Butyric Acid – Gut \u0026 Microbiome","description":"\u003carticle data-scroll-anchor=\"true\" data-testid=\"conversation-turn-32\" dir=\"auto\" class=\"text-token-text-primary w-full\"\u003e\n\u003cdiv class=\"text-base my-auto mx-auto py-5 \u0026lt;--thread-content-margin:--spacing(4)\u0026gt; @\u0026lt;37rem\u0026gt;:\u0026lt;--thread-content-margin:--spacing(6)\u0026gt; @\u0026lt;72rem\u0026gt;:\u0026lt;--thread-content-margin:--spacing(16)\u0026gt; px-(--thread-content-margin)\"\u003e\n\u003cdiv class=\"\u0026lt;--thread-content-max-width:32rem\u0026gt; @\u0026lt;34rem\u0026gt;:\u0026lt;--thread-content-max-width:40rem\u0026gt; @\u0026lt;64rem\u0026gt;:\u0026lt;--thread-content-max-width:48rem\u0026gt; mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\"\u003e\n\u003cdiv class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\"\u003e\n\u003cdiv class=\"relative flex-col gap-1 md:gap-3\"\u003e\n\u003cdiv class=\"flex max-w-full flex-col grow\"\u003e\n\u003cdiv data-message-model-slug=\"o4-mini\" data-message-id=\"fba4c550-afc0-44fa-9b5d-929404978523\" data-message-author-role=\"assistant\" dir=\"auto\" class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal \u0026lt;.text-message+\u0026amp;\u0026gt;:mt-5\"\u003e\n\u003cdiv class=\"flex w-full flex-col gap-1 empty:hidden first:pt-\u0026lt;3px\u0026gt;\"\u003e\n\u003cdiv class=\"markdown prose dark:prose-invert w-full break-words dark\"\u003e\n\u003cp data-is-only-node=\"\" data-is-last-node=\"\" data-end=\"151\" data-start=\"0\"\u003e\u003cspan class=\"a-list-item\"\u003e✔️\u003c\/span\u003e\u003cstrong\u003ePOWERFUL POSTBIOTIC ACTION.\u003c\/strong\u003e Calcium Butyrate delivers the postbiotic compound butyrate (from butyric acid) to support your digestive health and maintain immune function.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/article\u003e\n\u003cp\u003e\u003cspan class=\"a-list-item\"\u003e✔️\u003c\/span\u003e\u003cstrong\u003eINNOVATIVE MICROBIOME \u0026amp; IMMUNE SUPPORT.\u003c\/strong\u003e ButiShield™'s patented MicroPEARLS™ technology delivers over 35% butyric acid in a slow release, nourishing intestinal cells with vital energy, maintaining a robust gut barrier, encouraging a balanced microbiome and digestive environment, and acting as a signalling molecule to regulate key metabolic processes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e✔️100% VEGAN, NO SYNTHETIC BULKING OR ANTI-CAKING AGENTS, HIGH QUALITY GMP STANDARDS. \u003c\/strong\u003eAt Time Health we believe in clean nutrition which is why you won't find any nasty stuff in our products including any synthetic bulking or anti-caking agents. Manufactured in compliance with high quality GMP standards.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-list-item\"\u003e✔️\u003c\/span\u003e\u003cstrong\u003e100% RECYCLABLE POUCH \u0026amp; \u003ca href=\"https:\/\/ecologi.com\/timehealthltd\"\u003eTREE PLANTED\u003c\/a\u003e.\u003c\/strong\u003e To reduce environmental impact, our Calcium Butyrate is packaged in 100% recyclable materials. We are proud supporters of Ecologi's reforestation projects and plant a tree with every single order!\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003e🌳\u003ca href=\"https:\/\/ecologi.com\/timehealthltd\"\u003eOVER 100,000 TREES PLANTED AND COUNTING.\u003c\/a\u003e \u003c\/strong\u003eWe are proud supporters of Ecologi’s reforestation projects and contribute to tree planting efforts in the UK and abroad!\u003c\/span\u003e\u003cbr\u003e\u003c!-- notionvc: becc3b08-4272-4179-a673-551071b314b4 --\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-list-item\"\u003e\u003cb\u003e✔️ 100% RECYCLED AND RECYCLABLE BOTTLE.\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"x_1297565908highlight\"\u003e\u003cspan class=\"x_1297565908colour\"\u003e\u003cspan class=\"x_1297565908font\"\u003e\u003cspan class=\"x_1297565908size\"\u003eWe aim to close the loop on plastic.\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cb\u003e\u003cspan\u003e\u003cspan class=\"x_1297565908highlight\"\u003e\u003cspan class=\"x_1297565908colour\"\u003e\u003cspan class=\"x_1297565908font\"\u003e\u003cspan class=\"x_1297565908size\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"x_1297565908highlight\"\u003e\u003cspan class=\"x_1297565908colour\"\u003e\u003cspan class=\"x_1297565908font\"\u003e\u003cspan class=\"x_1297565908size\"\u003eO\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"x_1297565908colour\"\u003e\u003cspan class=\"x_1297565908font\"\u003e\u003cspan class=\"x_1297565908size\"\u003eur bottles are made entirely from recycled plastic (rPET) and are also 100% recyclable in standard kerbside recycling.\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003ePlease note: packaging may vary on this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer: \u003c\/strong\u003eThese statements have not been evaluated by any official health authority. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003cp\u003eCustomer reviews on our site are provided for informational purposes only and are not intended to diagnose, treat, cure or prevent any illness or disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSources:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32550943\/\"\u003eBanasiewicz T, Domagalska D, Borycka-Kiciak K, Rydzewska G. Determination of butyric acid dosage based on clinical and experimental studies – a literature review. Gastroenterology Review\/Przegląd Gastroenterologiczny. 2020;15(2):119-125. doi:10.5114\/pg.2020.95556.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21531334\/\"\u003eDonohoe, D.R., Garge, N., Zhang, X., Sun, W., O'Connell, T.M., Bunger, M.K. and Bultman, S.J., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell metabolism, 13(5), pp.517-526.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28654658\/\"\u003eYan, H. and Ajuwon, K.M., 2017. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. \u003ci\u003ePloS one\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(6), p.e0179586.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19625695\/\"\u003ePeng, L., Li, Z.R., Green, R.S., Holzman, I.R. and Lin, J., 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e139\u003c\/i\u003e(9), pp.1619-1625.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30322146\/\"\u003eBach Knudsen, K.E., Lærke, H.N., Hedemann, M.S., Nielsen, T.S., Ingerslev, A.K., Gundelund Nielsen, D.S., Theil, P.K., Purup, S., Hald, S., Schioldan, A.G. and Marco, M.L., 2018. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients, 10(10), p.1499.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32476236\/\"\u003eFacchin, S., Vitulo, N., Calgaro, M., Buda, A., Romualdi, C., Pohl, D., Perini, B., Lorenzon, G., Marinelli, C., D’Incà, R. and Sturniolo, G.C., 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterology \u0026amp; Motility, 32(10), p.e13914.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31607907\/\"\u003eGao, F., Lv, Y.W., Long, J., Chen, J.M., He, J.M., Ruan, X.Z. and Zhu, H.B., 2019. Butyrate improves the metabolic disorder and gut microbiome dysbiosis in mice induced by a high-fat diet. Frontiers in Pharmacology, 10, p.1040.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19222573\/\"\u003eLouis, P. and Flint, H.J., 2009. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. \u003ci\u003eFEMS microbiology letters\u003c\/i\u003e, \u003ci\u003e294\u003c\/i\u003e(1), pp.1-8.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29238752\/\"\u003eVital, M., Karch, A. and Pieper, D.H., 2017. Colonic butyrate-producing communities in humans: an overview using omics data. Msystems, 2(6), pp.e00130-17.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12840228\/\"\u003eDavie, J.R., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition, 133(7), pp.2485S-2493S.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24226770\/\"\u003eFurusawa, Y., Obata, Y., Fukuda, S., Endo, T.A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T. and Takahashi, M., 2013. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. \u003ci\u003eNature\u003c\/i\u003e, \u003ci\u003e504\u003c\/i\u003e(7480), pp.446-450.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10734024\/\"\u003eInan, M.S., Rasoulpour, R.J., Yin, L., Hubbard, A.K., Rosenberg, D.W. and Giardina, C., 2000. The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line. \u003ci\u003eGastroenterology\u003c\/i\u003e, \u003ci\u003e118\u003c\/i\u003e(4), pp.724-734.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27722928\/\"\u003ePatnala, R., Arumugam, T.V., Gupta, N. and Dheen, S.T., 2017. HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke. Molecular Neurobiology, 54(8), pp.6391-6411.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34757305\/\"\u003eZhang, M., Wang, Y., Zhao, X., Liu, C., Wang, B. and Zhou, J., 2021. Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review. Nutrition Research, 95, pp.1-18.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25875123\/\"\u003eKasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A. and Kimura, I., 2015. Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(4), pp.2839-2849\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32294476\/\"\u003eSperber, A.D., Bangdiwala, S.I., Drossman, D.A., Ghoshal, U.C., Simren, M., Tack, J., Whitehead, W.E., Dumitrascu, D.L., Fang, X., Fukudo, S. and Kellow, J., 2021. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study. \u003ci\u003eGastroenterology\u003c\/i\u003e, \u003ci\u003e160\u003c\/i\u003e(1), pp.99-114.\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/nutrition.org\/most-americans-are-not-getting-enough-fiber-in-our-diets\"\u003ehttps:\/\/nutrition.org\/most-americans-are-not-getting-enough-fiber-in-our-diets\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32395568\/\"\u003eMadison A, Kiecolt-Glaser JK. Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition. Curr Opin Behav Sci. 2019 Aug;28:105-110. doi: 10.1016\/j.cobeha.2019.01.011. Epub 2019 Mar 25. PMID: 32395568; PMCID: PMC7213601.\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Time Health","offers":[{"title":"Default Title","offer_id":52860777333065,"sku":"ButiShield60Pouch-WEB","price":18.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0963\/2186\/4009\/files\/1000Front_01f69ea6-c29b-4738-ae01-d0c9fd328be2.jpg?v=1760712260"},{"product_id":"gut-restore","title":"Gut Restore – 12 Strain Probiotic \u0026 Postbiotic Butyrate Generator – MicroBiomeX","description":"\u003cp\u003e✔️\u003cstrong\u003eADVANCED PROBIOTIC BLEND, 30 BILLION CFU.\u003c\/strong\u003e Our Gut Restore formula contains a combination of 12 powerful bacterial strains. The friendly bacteria in Gut Restore can help to balance the gut flora naturally present in the digestive system.\u003c\/p\u003e\n\u003cp\u003e✔️\u003cstrong\u003eGUT MICROBIOME MODULATION.\u003c\/strong\u003e Clinical research has shown that daily consumption of MicrobiomeX® beneficially modulates the gut microbiota. The growth of specific bacterial groups, namely Clostridium cluster XIVa is promoted and particularly the species belonging to the genus Roseburia spp, which are well-known for their butyrate-producing property and many beneficial health effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e✔️BUTYRATE PRODUCTION, \u003ca title=\"Good Gut Health\" href=\"\/blogs\/latest-blogs\/a-guide-to-good-gut-health\"\u003eGUT BARRIER FUNCTION\u003c\/a\u003e. \u003c\/strong\u003eAfter 12 weeks of MicrobiomeX® consumption, a significant increase in the butyrate was observed. Butyrate has health-promoting effects such as positively affecting gut barrier function and lowering gut inflammation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e✔️IMMUNE BOOSTING. \u003c\/strong\u003eIn one study, daily supplementation of MicrobiomeX® resulted in a strong reduction in calprotectin was shown compared to the placebo group. Calprotectin is an important biomarker of gut inflammation, and its reduction suggests a decrease in pathogen load in the gut.\u003c\/p\u003e\n\u003cp\u003eOther recent clinical evidence demonstrated that MicrobiomeX® significantly increases the secretion of antibodies (IgA) in the gut lumen, indicating better protection against colonisation by pathogens.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e✔️100% VEGAN, NO SYNTHETIC BULKING OR ANTI-CAKING AGENTS, HIGH QUALITY GMP STANDARDS. \u003c\/strong\u003eAt Time Health we believe in clean nutrition which is why you won't find any nasty stuff in our products including any synthetic bulking or anti-caking agents. Manufactured in compliance with high quality GMP standards.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003e🌳\u003ca href=\"https:\/\/ecologi.com\/timehealthltd\"\u003eOVER 100,000 TREES PLANTED AND COUNTING.\u003c\/a\u003e \u003c\/strong\u003eWe are proud supporters of Ecologi’s reforestation projects and contribute to tree planting efforts in the UK and abroad!\u003c\/span\u003e\u003c!-- notionvc: db17e9ca-b858-40fe-8b75-876498011ffb --\u003e\u003c\/p\u003e\n\u003cp\u003ePlease note: packaging may vary on this product.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eDisclaimer\u003c\/b\u003e:\u003c\/p\u003e\n\u003cp\u003eThese statements have not been evaluated by any official health authority. These products are not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003cp\u003eCustomer reviews on our site are provided for informational purposes only and are not intended to diagnose, treat, cure or prevent any illness or disease.\u003c\/p\u003e","brand":"Time Health","offers":[{"title":"120 Capsules","offer_id":52860778676553,"sku":"GutRestore-120Bottle-WEB","price":26.99,"currency_code":"GBP","in_stock":true},{"title":"60 Capsules","offer_id":52860778709321,"sku":"GutRestore-60-WEB","price":15.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0963\/2186\/4009\/files\/1000Front-1_00e70d16-bf21-4273-9f80-3ce4670605ce.jpg?v=1756489333"}],"url":"https:\/\/timehealth.co.uk\/collections\/newsletter.oembed","provider":"Time Health UK","version":"1.0","type":"link"}